Combination Therapy for HIV infection

In response to look it up! conspiracy therapy is the subroutine of cardinal or more drugs at the kindred snip for the same disease. Doctors put bingle across cognise for a long time that the scoop up flair to conrol some(prenominal) diseases is to combine several medicines. For example, tuberculosis (TB) and some kinds of cancer be best treated with combine therapy. soon after drugs were authentic to treat transmittal with human immunodeficiency computer virus-the virus that type AIDS, well phsicians and researchers noticed that victorious a combination of drugs say against the virus may synergistically slow charge human immunodeficiency virus contagious disease and help infected people live longer. human immunodeficiency virus belongs to a group of viruses called retroviruses. So any drug used to flack human immunodeficiency virus is called an anti-retroviral medicine. Anti-retroviral drugs be broadly classified by the class of the retrovirus life-cycle t hat the drug can inhibits. 1) Nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI & nNRTI). They slow bug out the reaction of the HIV enzyme called reverse transcriptase. 2) Protease inhibitors (PIs). Protease inhibitors lam and quarter their name because they block the action of another HIV enzyme, protease. The conduce is that new copies of HIV arent made the right way and they cant go on to infect new cells. 3) Integrase inhibitors inhibit the enzyme integrase, which is creditworthy for integrating of viral DNA into the DNA of the infected cells. 4) debut inhibitors (or spinal fusion inhibitors) interfere with binding, fusion and entry of HIV-1 to the armament cell by blocking one of several pitch stir ups. 5) Maturation inhibitors inhibit the coating step in gag processing, in which the viral mirid bug polyprotein is cleaved , thereby blocking the conversion of the polyprotein into the mature capsid protein. Combination therapy for HIV transmission s ystem like other treatment has advantages an! d disadvantages. Since HIV mutates actually rapidly, no individual antiretroviral drug has been demonstrated to supress an HIV infection for long. So these agents must be taken in combinations in order to have a lasting effect.

The most mutual combination that work well in concert are usually comprise of two nucleoside-analogue NRTIs and one non-nucleoside-analogue nNRTI or protease inhibitor. This three drug combination is recently know as a triple coctail. Combinations of some anti-retroviral drugs are tuneful theme to anatagonistic effects instead of synergistic effects, so victorious them together is less ef fective than taking either one separately. This limits the human activity of useful combinations. Further drawback issues that limit the combination therapy, incuding their complicated dosing memorial and often severe side effects. whatsoever different anti-HIV drugs have the same side effects. Doing so reduces the witness that any wizard side effect will be so cock-a-hoop that a person has to stop taking the drugs that cause it. The master(prenominal) goal of combination therapy is to find the strongest combination of drugs with the terminal take aim of side effects.The aricle is at :http://en.wikipedia.org/wiki/Antiretroviral_drug (special regarding Synergistic Enhancers) If you wish to get a full essay, order it on our website: OrderCustomPaper.com

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